Reversing Alzheimer’s




Salsalate is an NSAID (Non-Steroidal Anti-Inflammatory - in the same class of drug as asprin) that is sold by prescription only. A typical medical order would read "take one tablet (500 mg) by mouth up to three times a day". As with any prescription medicine, there are risks and side-effects.[1] With permission, and working with your medical provider, you might try one tablet a day for thirty days and see if you notice any change in your mentation.

Here is the latest research on the drug.

Researchers from the Gladstone Institute have found that Salsalate – a medication that belongs to the salicylate and Non-Steroidal Anti-Inflammatory Drug (NSAID) classes – helps prevent the accumulation of tau in the brain and even cognitive impairment comparable to impairments of Alzheimer’s disease (AD) and Frontotemporal Dementia. (FTD) [2]

Gladstone Institutes. "Old drug offers new hope to treat Alzheimer's disease: By repurposing a prescription drug used to treat rheumatoid arthritis, researchers successfully reversed tau-related symptoms in an animal model of dementia." ScienceDaily, 21 September 2015.[3].

Wikipedia Entry[4]

Salsalate is a medication that belongs to the salicylate and non-steroidal anti-inflammatory drug (NSAID) classes. Relative to other NSAIDs, salsalate has a weak inhibitory effect on the cyclooxygenase enzyme and decreases the production of several pro inflammatory chemical signals such as interleukin-6, TNF-alpha, and C-reactive protein. Common conditions in which salsalate may be indicated include inflammatory disorders such as rheumatoid arthritis or noninflammatory disorders such as osteoarthritis. Salsalate is the generic name of a prescription drug marketed under the brandnames Mono-Gesic, Salflex, Disalcid, and Salsitab. Other generic and brand name formulations may be available.